The lab has a strong publication record, with several articles published yearly in journals with high impact factors. Members of the lab work not only on molecular research projects, but also on clinical research as well. Each lab member also typically works on a review article of either a clinical or molecular nature. Dr. Gupta works to ensure that students are assigned to projects that accord with their future career interests.


Rafijah G et al. The effects of adjuvant fibrin sealant on the surgical repair of segmental nerve defects in an animal model. The Journal of hand surgery. 38, (5):847-55 (2013).

Chao T et al. Matrix metalloproteinase 3 deletion preserves denervated motor endplates after traumatic nerve injury. Annals of neurology 73, 210–23 (2013).

Lin MY et al. Biophysical Stimulation induces demyelination via an integrin-dependent mechanism. Annals of Neurology. 72, (1):112-23 (2012).

Gupta R et al. Chronic nerve compression alters Schwann cell myelin architecture in a murine model. Muscle & Nerve. 45(2):231-41 (2012).

Chao T, Pham K, Steward O, Gupta R. Chronic nerve compression injury induces a phenotypic switch of neurons within the dorsal root ganglia. J. Comp. Neurol. 506(2):180-93 (2008).

Dinh P, Bhatia N, Rasouli A, Suryadevara S, Cahill K, Gupta R. Transplantation of preconditioned Schwann cells following hemisection spinal cord injury. Spine. 32(9):943-49 (2007).

Gray M, Palispis W, Popovich PG, van Rooijen N, Gupta R. Macrophage depletion alters the blood-nerve barrier without affecting Schwann cell function after neural injury. J. Neurosci. Res. 85(4):766-77 (2007).

Rasouli A, Bhatia N, Suryadevara S, Cahill K, Gupta R. Transplantation of preconditioned schwann cells in peripheral nerve grafts after contusion in the adult spinal cord. Improvement of recovery in a rat model. J. Bone Joint Surg. Am. 88(11):2400-10 (2006).

Berger BL, Gupta R. Demyelination secondary to chronic nerve compression injury alters Schmidt-Lanterman incisures. J. Anat. 209(1):111-18 (2006).

Gupta R, Rummler LS, Palispis W, Truong L, Chao T, Rowshan K, Mozaffar T, Steward O. Local down-regulation of myelin-associated glycoprotein permits axonal sprouting with chronic nerve compression injury. Exp. Neurol. 200(2):418-29 (2006).

Gupta R, Channual JC. Spatiotemporal pattern of macrophage recruitment after chronic nerve compression injury. J. Neurotrauma. 23(2):216-26 (2006).

Gupta R, Truong L, Bear D, Chafik D, Modafferi E, Hung CT. Shear stress alters the expression of myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) in Schwann cells. J. Orthop. Res. 23(5):1232-39 (2005).

Gupta R, Gray M, Chao T, Bear D, Modafferi E, Mozaffar T. Schwann cells upregulate vascular endothelial growth factor secondary to chronic nerve compression injury. Muscle Nerve. 31(4):452-60 (2005).

Azanchi R, Bernal G, Gupta R, Keirstead HS. Combined demyelination plus Schwann cell transplantation therapy increases spread of cells and axonal regeneration following contusion injury. J. Neurotrauma. 21(6):775-88 (2004).

Gupta R, Rowshan K, Chao T, Mozaffar T, Steward O. Chronic nerve compression induces local demyelination and remyelination in a rat model of carpal tunnel syndrome. Exp. Neurol. 187(2):500-8 (2004).

Gupta R, Lin YM, Bui P, Chao T, Preston C, Mozaffar T. Macrophage recruitment follows the pattern of inducible nitric oxide synthase expression in a model for carpal tunnel syndrome. J. Neurotrauma. 20(7):671-80 (2003).

Chafik D, Bear D, Bui P, Patel A, Jones NF, Kim BT, Hung CT, Gupta R. Optimization of Schwann cell adhesion in response to shear stress in an in vitro model for peripheral nerve tissue engineering. Tissue Eng. 9(2):233-41 (2003).

Gupta R, Steward O. Chronic nerve compression induces concurrent apoptosis and proliferation of Schwann cells. J. Comp. Neurol. 461(2):174-86 (2003).

Gupta, R; Allen, FA; Tan, V; Bozentka, DJ; Bora, FW; sterman, AL. The effect of laminar fluid flow on fibroblasts derived from Dupytren's tissue and normal palmar fascia. J. Hand Surgery. 23A:945-50 (1998).

Lorich, DG; Brighton, CT; Gupta, R; Corsetti, JR; Levine, SE; Gelb, ID; Seldes, R, Pollack, SR. Biochemical pathway mediating the response of bone cells to capacitive coupling. Clinical Orthop. & Rel. Res. 350:246-56 (1998).

Bernot, M, Gupta, R, Dobrasz, B, Chance, B, Heppenstall, RB, Sapega, AA. The effect of antecedent ischemia on the tolerance of skeletal muscle to increased interstitial pressure. J. Orthop. Trauma 10(8):555-59 (1996).

Shapiro TA, McGarry MH, Gupta R, Lee YS, Lee TQ. Biomechanical effects of glenoid retroversion in total shoulder arthroplasty. J. Shoulder Elbow Surg. 16(3 Suppl):S90-95 (2007).

Karamanoukian R, Gupta R, Evans GR. A novel technique for the prophylactic plating of the osteocutaneous radial forearm flap donor site. Ann. Plast. Surg. 56(2):200-04 (2006).

Gupta R, Bingenheimer E, Fornalski S, McGarry MH, Osterman AL, Lee TQ. The effect of ulnar shortening on lunate and triquetrum motion--a cadaveric study. Clin. Biomech. 20(8):839-45 (2005).

Gupta R, Lee TQ. Positional-dependent changes in glenohumeral joint contact pressure and force: possible biomechanical etiology of posterior glenoid wear. J. Shoulder Elbow Surg. 14(1 Suppl S):105S-110S (2005).

Kobayashi MR, Brenner KA, Gupta R, Evans GR. Functional biceps brachii reconstruction using the free tensor fasciae latae. Plast. Reconstr. Surg. 114(5):1208-14 (2004).

Gupta R, Jones NF. A novel method of skeletal fixation in an above-elbow replantation: the dowel pin technique. Plast. Reconstr. Surg. 111(7):2349-52 (2003).

Gupta R, Allaire RB, Fornalski S, Osterman AL, Lee TQ. Kinematic analysis of the distal radioulnar joint after a simulated progressive ulnar-sided wrist injury. J. Hand Surg. 27(5):854-62 (2002).

Gupta, R; Villablanca, PJ; Jones, NF Evaluation of an acute compression injury in an animal model by magnetic resonance neurography. J. Hand Surg. 26A: 1093-99 (2001).

Gupta R, Rummler L, Steward O. Understanding the biology of compressive neuropathies. Clin. Orthop. Relat. Res. (436):251-60 (2005).

Rummler L, Gupta R. Peripheral nerve repair: a Review. Curr. Opin. Orthop. 15:215-19 (2004).

Rummler, LS; Dinh, PT; Gupta, R. The anatomy and biochemistry of myelin and myelination. Oper. Tech. Orthop. 14(3):146-152 (2004)

Kang J, Gupta R. Mechanisms of fatty degeneration in massive rotator cuff tears. Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.] 21, 175–80 (2012).

Kang JR, Zamorano DP, Gupta R. Limb Salvage with major nerve injury: current management and future directions. J Am Acad Orthop Surg 19, S28-S34 (2011).

Tafti MA, Cramer SC, Gupta R. Orthopaedic management of the upper extremity of stroke patients. J Am Acad Orthop Surg. 16(8):462-70 (2008).

Strandberg EJ, Mozaffar T, Gupta R. The role of neurodiagnostic studies in nerve injuries and other orthopedic disorders. J Hand Surg. 32(8):1280-90 (2007).

Gupta R, Lee TQ. Contributions of the different rabbit models to our understanding of rotator cuff pathology. J. Shoulder Elbow Surg. 16(5 Suppl):S149-57 (2007).

Ecklund KJ, Lee TQ, Tibone J, Gupta R. Rotator cuff tear arthropathy. J. Am. Acad. Orthop. Surg. 15(6):340-9 (2007).
Fornalski S, Gupta R, Lee TQ. Anatomy and biomechanics of the elbow joint. Tech. Hand Up. Extrem. Surg. 7(4):168-78 (2006).

Dinh PT, Gupta R. Subtotal medial epicondylectomy as a surgical option for treatment of cubital tunnel syndrome. Tech. Hand Up. Extrem. Surg. 9(1):52-59 (2005).

Chafik D, Lee TQ, Gupta R. Total elbow arthroplasty: current indications, factors affecting outcomes, and follow-up results. Am. J. Orthop. 33(10):496-503 (2004).

Rowshan K, Jones N, Gupta R. Current surgical techniques of peripheral nerve repair. Oper. Tech. Orthop. 214(3):163-70 (2004).

Gupta R, Mozaffar T. Peripheral Nerve Physiology, Anatomy, and Pathology. In: Buckwalter JA, Einhorn TA, O'Keefe RJ (eds). Orthopedic Basic Science: Biology and Biomechanics of the Musculoskeletal System. 3rd Ed.

American Academy of Orthopedic Surgeons, Rosemont, Illinois (in press).

Gupta R, Mozaffar T. Form and Function of the Spinal Cord and Peripheral Nerves. In: Buckwalter JA, Einhorn TA, O'Keefe RJ (eds). Orthopedic Basic Science: Biology and Biomechanics of the Musculoskeletal System. 3rd Ed. American Academy of Orthopedic Surgeons, Rosemont, Illinois (in press).



For the second time in three years, the Orthopaedic Research & Education Foundation (OREF) has chosen one of UC Irvine Orthopaedic residents to receive their prestigious OREF Resident Clinician Scientist Training Grant. The 2014 recipient of this award is Dr. Minal Tapadia.


Dr. Ranjan Gupta has been selected as an ABC Traveling Fellow, one of the most prestigious orthopaedic awards and honors.


Click to visit UC Irvine Health Department of Orthopaedic Surgery